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Games like Immunica | IndieDex

Immunica
Games like Immunica

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Games like Immunica

A casual strategy game where you play the immune system, auto-fighting pathogen hordes and managing a lab to develop a vaccine, though frustrating and grindy execution wears thin.

Antivirus PROTOCOL
A compact incremental strategy game about upgrading an antivirus to destroy a global virus, with rewarding but sometimes slow progression.
2025-09-17
- Action
- Strategy

Indie

Simulator

Sporbs cover art

Sporbs

A short, mouse-only incremental about popping alien organisms, with light automation and upgrades—charming but repetitive over its ~2-3 hour runtime.

2026-05-20

Indie

Life on the Edge cover art

Life on the Edge

An educational tower defense game where you defend a cell from pathogens, mixing biology lessons with tactical defense in a short, single-player session.

2022-06-17

Action
Strategy
Simulator

Defend Your Life: TD cover art

Defend Your Life: TD

A casual tower defense game inside the human body, where you fend off viruses with anatomical-themed units.

2015-04-10

Action
Strategy
Bird view / Isometric
Indie

Microcosmum: survival of cells cover art

Microcosmum: survival of cells

A casual action-strategy game about surviving as a single-celled organism in a microscopic world, with light RPG progression and a roughly 8-hour playtime.

2015-07-24

Action
Strategy
Indie
Simulator
Role-playing (RPG)

DO NOT FEED THE VIRUS cover art

DO NOT FEED THE VIRUS

A short, casual mouse-driven incremental sim about growing a biomass colony, with level-based twists, ~3.5 hours of playtime, and mixed reviews citing simplicity and save-file issues.

2026-05-14

Action
Strategy
Indie
Simulator
Arcade

Increbraintal cover art

Increbraintal

A short, casual incremental auto battler about building a team and upgrading through a Skill Tree to eliminate a body-wide viral contamination.

2026-04-24

Strategy
Simulator

Undead Inc. cover art

Undead Inc.

A medical-corporation management sim mixing legitimate treatments and bioweapons trade, but reviewers report broken AI and unfinished systems make its high-risk gameplay more frustrating than fun.

2024-05-02

Action
Strategy
Side view
Simulator
Text

Germ Wars cover art

Germ Wars

A single-player action game where you fight germs as a white blood cell, with ramming and upgrade mechanics and mixed reviews.

2016-11-21

Action
Indie

Expand & Exterminate: Terrytorial Disputes - Endless Base Defense cover art

Expand & Exterminate: Terrytorial Disputes - Endless Base Defense

An Early Access single-player RTS/tower-defense hybrid about expanding a base and researching upgrades against endless waves, with reviewers warning of repetitive skirmish-only content and little future support.

2023-06-27

Strategy
Indie

Supre-Immune cover art

Supre-Immune

A lighthearted roguelike action game where you battle viruses, collect data, and evolve your immune cell in short runs averaging about 80 minutes.

2026-06-30

Action
Strategy
Indie

Infectious cover art

Infectious

A short action-simulation game about playing as a virus that infects organs and battles immune cells, with mixed reviews and praised visuals.

2020-08-20

Action
Indie
Simulator