Defend Your Life: TD
Games like Defend Your Life: TD

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Games like Defend Your Life: TD

A casual tower defense game inside the human body, where you fend off viruses with anatomical-themed units.

Life on the Edge
An educational tower defense game where you defend a cell from pathogens, mixing biology lessons with tactical defense in a short, single-player session.
2022-06-17
- Action
- Strategy

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Games like Defend Your Life: TD | IndieDex

Defend Your Life: TD
Games like Defend Your Life: TD

Find the Steam hidden gems

actions with secrets you find without a guideor

Edit search

Games like Defend Your Life: TD

A casual tower defense game inside the human body, where you fend off viruses with anatomical-themed units.

Life on the Edge
An educational tower defense game where you defend a cell from pathogens, mixing biology lessons with tactical defense in a short, single-player session.
2022-06-17
- Action
- Strategy

Simulator

Decently Bad Tower Defense

A short, casual tower defense game with three towers and three enemy types where strategic placement wins.

2020-05-25

Strategy
Indie

Immortal Defense

A story-driven tower defense game about sacrificing yourself to defend your home world, with punishing difficulty and an emotionally resonant narrative; reviewers' median playtime is about 7.5 hours.

2015-08-31

Action
Science fiction
Strategy
Indie
Side view

Antivirus Girl

A casual ~10-hour single-player defense shooter where you inspect files and blast malware in an arcade-style mix of tower defense and direct action.

2026-07-01

Action
Strategy
Indie
Simulator
Real Time Strategy (RTS)

Freedom Defender

A satirical single-player tower defense game about border control, with a short campaign averaging a few hours.

2017-08-25

Strategy
Indie

Immunica

A casual strategy game where you play the immune system, auto-fighting pathogen hordes and managing a lab to develop a vaccine, though frustrating and grindy execution wears thin.

2026-03-29

Strategy
Indie

Going Viral

A short, casual action-sim where you play a T-Cell defending the body by consuming pathogens and upgrading allies, with educational biology themes and light puzzle elements.

2026-03-25

Action
Simulator

Hydra TD

A chill, stylized tower defense game about strategic tower placement and upgrades, with a short campaign and an Endless mode.

2026-03-02

Listeria Wars

A real-time tactical tower defense game set inside an infected human body, with a parallel view of the host's life during battle.

2022-12-08

Strategy
Indie
Simulator

Defend the Cake

A colorful, humorous single-player tower defense game about building toast-wall mazes and using real-time power-ups to fend off bug waves, with a roughly 8.5-hour campaign.

2017-12-01

Strategy
Indie

Defendron TD

A compact cyberpunk tower defense game with modular upgrades and wave-based combat, offering a short but deep strategy experience.

2023-09-14

Strategy

Domain Defense VR

A compact VR tabletop tower defense game with intuitive motion controls, though bugs and crashes mar an otherwise enjoyable experience.

2017-05-11

Strategy
Indie

Life on the Edge